月別アーカイブ: 2014年1月

Comprehensive Pharmacy Services Advises Hospitals to Plan for Protracted Intravenous Saline Shortage

MEMPHIS, Tenn., Jan. 31, 2014 (GLOBE NEWSWIRE) — Comprehensive Pharmacy Services (CPS), the nation’s largest pharmacy services provider, issued an advisory to its more than 400 hospitals and health systems clients throughout the country to prepare for a protracted intravenous (IV) saline shortage, and provided a three-part plan to help them manage the critical shortage.

“We’ve been doing this for 40 years, and we don’t see a clearly defined end to the current intravenous saline shortage so we are calling on the healthcare facilities we serve to take immediate action to help effectively manage through this crisis,” said Marvin Finnefrock, Pharm. D., Divisional Vice President for Clinical Services. “It can’t be business as usual because the shortage is lasting longer than expected, so hospitals have to immediately focus energy, beyond finding the scarce supply, on managing what they have and engaging in thoughtful measures to best serve their patients.”

Dr. Finnefrock explained that the IV saline shortage is particularly concerning because it is one of the most commonly used drugs in patient treatments. “As other avenues are pursued, such as the Food and Drug Administration (FDA) working with the manufacturers to step up production or the federal government releasing some emergency stockpiles, those solutions have hurdles and are well outside the control of healthcare providers, so they need to take matters into their own hands, as well,” Dr. Finnefrock added.

CPS is advising that medical, nursing and pharmacy staff work together on a three-part approach to manage through the IV saline shortage:

  1. Conservation: Immediately conduct a wastage review in all areas where IV saline is routinely used without a specific direct indication, for example, in elective procedural areas and emergency departments, and set up basic guidelines leading to conservation of a limited resource.
  2. Substitution: Hospitals should put in place plans for adequate substitution regimens as indicated, in case the shortage worsens or lasts for a prolonged period of time. This, however, requires careful oversight from a qualified pharmacy and clinician team to safely and effectively use substitutions on a patient-by-patient basis.
  3. Communication: Implement a timely communication plan to all clinical staff involved in ordering or administering IV saline, keeping them informed of the status of the shortage and supplies available to the facility. The goal of the communication is to engage staff in conservation efforts and keep them informed of actions planned by clinical leadership to mitigate shortage challenges.

About Comprehensive Pharmacy Services:

Employing over 1,800 pharmacy professionals, CPS is the nation’s largest provider of pharmacy services to more than 400 hospitals and healthcare facilities leading to sustainable improved quality and reduced cost. CPS services include pharmacy consulting, inpatient and outpatient pharmacy management, telepharmacy and transition of care services. For more information, visit www.cpspharm.com.

Source Article from http://finance.yahoo.com/news/comprehensive-pharmacy-services-advises-hospitals-140000210.html
Comprehensive Pharmacy Services Advises Hospitals to Plan for Protracted Intravenous Saline Shortage
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Senior Product Chemist


Desired Expertise: Chemist
Experience: 3+ years
Minimum Education: Bachelors/3-5 yr Degree
Location: Sugar Land, TX, US
Reference Code: 37490BR
Job Status:

Active / Open

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Job Description:

Main Responsibilities:

  • Responsible for the technical evaluation and maintenance of production processes and product lines
  • Ability to rapidly troubleshoot small molecule and polymer synthesis reaction and blends
  • Ability to critically discern reaction failure pathways
  • Perform root cause analysis of analytical, synthetic and manufacturing problems
  • Evaluate reaction feasibility upon scale up from bench and pilot plant scale to full production
  • Perform process optimization in conjunction with research, pilot plant, and plant engineering
  • Implement and optimize test methods for quality assurance analyses
  • Prepare bench scale batches for process troubleshooting, when necessary
  • Address customer complaints and field problems
  • Serve as an internal ISO auditor
  • Assist smaller plants with QA issues and product maintenance
  • Serve as a liaison between QA and other areas of the company, customers and suppliers

Basic Qualifications:

  • Education and experience required as follows:

    • PhD in Organic or Analytical Chemistry
    • OR Master’s Degree in Organic or Analytical Chemistry with 3+ years of experience
    • OR Bachelor’s Degree in Chemistry with 5+ years of experience
  • 2+ Years of experience with process troubleshooting in a lab environment
  • 2+ Years of experience in wet chemical and instrumental analysis, especially GC, LC and FTIR
  • Immigration sponsorship not offered for this role

Preferred Qualifications:

  • Masters or PhD in Organic chemistry is strongly desired
  • 2+ Years of experience supporting large scale manufacturing
  • Relational database proficiency (MS Access)
  • Experience with statistical analysis and statistical process control techniques
  • Strong computer skills (SAP, Lotus Notes, MS Office)

Apply Now

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Source Article from http://www.rigzone.com/jobs/postings/439060/Senior_Product_Chemist.asp
Senior Product Chemist
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Pharmacist: Acetaminophen is Number One Cause of Liver Failure

SPRINGFIELD, Mo. – The FDA is issuing a warning about the dangers of the pain reliever acetaminophen, commonly known as Tylenol.

Approximately 50 million Americans use Tylenol each week.

It doesn’t pose a danger by itself, but if used incorrectly, can cause serious damage to your body.

“In this country, Acetaminophen is the number one cause of acute liver failure,” says Terry Barks, a Mercy clinical pharmacist. “And acute liver failure leads to thousands of ER visits, and thousands of hospital admissions, and hundreds of deaths every year.”

In the last decade, more than 1,500 Americans died from accidental ingestion of acetaminophen, according to Propublica.

The danger doesn’t lie in the drug itself, but in taking more than the maximum recommended daily dose, in combination with alcohol, or most commonly, with other drugs.

“The danger relates to taking multiple products, and not realizing that two or more have acetaminophen in them,” says Barks.

Cox South Hospital has documented 11 accidental Tylenol overdose cases in 2013. That’s more than double the cases in 2012.

“This does represent a small picture of what’s out there, especially when it comes to the accidental overdose which is a huge concern for us because long-term consumption of Tylenol can be very detrimental over a long period of time,” says Jason Martin, Cox Hospital Injury Prevention & Outreach Coordinator.

It takes about four hours for the liver to process acetaminophen. Too much Tylenol can overwhelm the body, causing a toxic compound to accumulate in the liver. This creates liver damage.

“Once your liver fails, it causes your entire body system to start breaking down,” says Martin. “And ultimately, that’s what can kill people, or that’s what can give people chronic problems.”

Symptoms of overdose include stomach pain, nausea, and vomiting, but may take more than 24-hours to appear.

“Acetaminophen toxicity is what I call kind of a hit and run thing,” says Barks. “The damage is done before you even become aware of it.”

The Federal Drug Administration has tried to regulate acetaminophen.

In 2011, the FDA requested the removal of combination drug products containing more than 325 milligrams of acetaminophen and recently requested doctors and pharmacists to do the same with prescriptions.
The current FDA recommendation is to take no more than 4000 mg in a 24-hour period. But it doesn’t control how many bottles you can buy over the counter, and thus, how many capsules you can ingest.

“The biggest misconception that people have is it’s safe,” says Barks. “And a lot of that comes from the fact that it is so easily obtainable.”

Martin and Barks say overdose prevention starts with reading drug labels, consulting with your doctor and pharmacist about all of your prescribed and over-the-counter medications, and to ultimately be wary of taking Tylenol.

“It’s not necessary to treat every presentation of pain or fever,” says Barks. “Pain serves a purpose. If it hurts when you do that, pain tells you don’t do that.”

Many pharmacies KOLR10 visited have already pulled extra-strength Tylenol off the shelves.

The FDA has implemented certain over-the-counter regulations, including adding information on the potential for liver injury on acetaminophen-containing drugs, as well as highlighting the drug on labels.

The FDA added it plans to further regulate over the counter acetaminophen products in a separate regulatory action.

Source Article from http://www.ozarksfirst.com/story/d/story/pharmacist-acetaminophen-is-number-one-cause-of-li/13601/YSJ7W2AviUK7ZHzqpLN_Kg
Pharmacist: Acetaminophen is Number One Cause of Liver Failure
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